Important Safety Information for GLP-1 Medications
Warning: Risk of Thyroid C-Cell Tumors
In studies with rodents, GLP-1 receptor agonists such as semaglutide and tirzepatide caused thyroid tumors, including thyroid cancer. It is not known if these medications cause thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans.
Do not use these medications if you or a family member have ever had MTC or have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Tell your healthcare provider right away if you notice a lump or swelling in your neck, hoarseness, difficulty swallowing, or shortness of breath.
Approved Uses
Semaglutide is approved for chronic weight management in adults with obesity (BMI ≥30) or overweight (BMI ≥27) with at least one weight-related condition, in combination with reduced-calorie diet and increased physical activity.
Ttirzepatide is approved for chronic weight management in adults with obesity or overweight plus a weight-related condition.
Do Not Use GLP-1 Medications If:
You or a family member have ever had MTC or MEN 2
You have a known allergy to semaglutide, tirzepatide, or any ingredients in these medications
You are pregnant or planning to become pregnant (these medications should be discontinued at least 2 months before a planned pregnancy)
Tell Your Healthcare Provider If You Have Ever Had:
Type 1 or 2 diabetes
Thyroid cancer or nodules
Pancreatitis
Kidney or gallbladder disease
Diabetic retinopathy
Depression or suicidal thoughts
Severe gastrointestinal (stomach or intestinal) problems
Always share a full list of your medications, including prescriptions, over-the-counter drugs, vitamins, and supplements.
Serious Possible Side Effects Include:
Thyroid C-cell tumors (see Warning above)
Inflammation of the pancreas (pancreatitis)
Gallbladder problems, including gallstones
Low blood sugar (especially if used with insulin or sulfonylureas)
Acute kidney injury (due to dehydration from vomiting or diarrhea)
Severe gastrointestinal reactions (nausea, vomiting, constipation)
Increased heart rate
Suicidal thoughts or behavior
Allergic reactions (rash, swelling of the face/tongue/throat, breathing difficulty)
Seek immediate medical attention if you experience any of these symptoms.
Most Common Side Effects Include:
Nausea, vomiting, diarrhea, constipation, abdominal pain, indigestion, headache, dizziness, fatigue, and injection-site reactions. These symptoms often decrease as your body adjusts to treatment.
Additional Safety Notes
Never share pens, vials, or needles with another person.
These medications may delay stomach emptying and affect how other medicines are absorbed.
They are not for treatment of type 1 diabetes.
Weight loss medications should not be used during pregnancy.
Adverse Event Reporting
Disclaimer
This information is provided for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health professional with any questions you may have regarding a medical condition or medication. Do not disregard professional medical advice or delay in seeking it because of something you have read on this site.